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KMID : 0869620210380040462
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Journal of Korean Society of Hospital Pharmacists
2021 Volume.38 No. 4 p.462 ~ p.472
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Clinical Efficacy of Starter Parenteral Nutrition in Very Low Birth Weight Infants
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Sung Jee-Hyun
Lim Na-Ri
Jeon Eun-Yong
Lee Hu-Kyoung
Sung Se-In
Min Myung-Sook
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Abstract
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Background : Preterm infants including very low birth weight infants (VLBWIs) and extremely low birth weight infants (ELBWIs) have high rates of protein turnover and low nutrient reserves. Therefore, parenteral nutrition (PN) should be initiated within 24 hours after birth if it is anticipated that they will be unable to tolerate enteral feeding for more than 2 to 3 days. However, in our institution, in cases of babies born on holidays and weekends, it is difficult to supply individualized PN including amino acids. So we supply starter PN (SPN) every Saturday and holiday, for use in case of emergency. We intended to evaluate the clinical efficacy of SPN on short-term growth and nutritional supply, especially for preterm infants.
Methods : We retrospectively reviewed the medical records of preterm infants with a birth weight of less than 1,500 g who were born and admitted to the neonatal intensive care unit (NICU) of the Samsung Medical Center between March 2015 and May 2020. The patients were categorized into two groups according to whether they received SPN or not. We compared perinatal characteristics, nutrition supply, anthropometric measurements, and laboratory findings between the two groups.
Results : Of the 82 patients, 40 infants were in the SPN group. Gestational age (p<0.001) and one minute Apgar score (p<0.001), and calories supplied over the first two weeks were lower in the SPN group (p=0.014). However, the rate of weight gain was higher in the SPN group (p=0.007). Most laboratory test results were significantly different between the two groups.
Conclusion : SPN can improve the short-term growth of preterm infants. Lower gestational age seems to be the cause of relatively high values of laboratory test results including BUN and blood glucose as well as low caloric intake in the SPN group.
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KEYWORD
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Parenteral nutrition, Neonatal intensive care, Preterm, Starter parenteral nutrition, Very low birth weight infant
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